Overview

AmProtein is a biotech company founded in 2002 by Matthew Hui, MD, PhD, formerly a key protein production scientist at Amgen. AmProtein has developed a reputation as a biotechnology powerhouse that has revolutionized the modern biotechnology industry with the discovery of a DNA physical structure-based gene expression mechanism, common to all eukaryotic cells, and a novel, non-sparging-dependent O₂ transfer method.

AmProtein has termed this mechanism the 'GC-rich method.' It has led to a second revolution after the gene amplification method, and has surely resulted in a new era in commercialized biologics research worldwide. Based on the GC-rich method, AmProtein has developed and commercialized a gene expression vector series for mammalian cells, chicken cells, fish cells, and possibly plant cells. By using the GC-rich method, one can reach commercial level protein titers after only a few laboratory-scale stable gene transfections.

Based on the above non-sparging O₂ transfer method, we have successfully commercialized a single-use, plastic bag-based bioreactor series as an effective dissolved oxygen (DO) generator for high-density suspension cell culture.

In addition, AmProtein has successfully developed a high-density perfusion cell culture system by using a single-use, cell attachment paper-carrier material and our suspension culture system as a DO generator.

AmProtein has applied its expression system for the rapid production and subsequent development of our dual domain drug product candidates, the next IP frontier in biologics. AmProtein's vector series and protein production platform are ideal for the rapid development of recombinant protein, antibody, and generic drugs. Both AmProtein's revolutionary expression vector and superior bioreactor series are available for licensing. Also, AmProtein has the capability to support the projects of other companies through its Contract Research division.

AmProtein is open to fostering partnerships around the globe for the co-development of its technologies. Currently we enjoy fruitful collaborations is China and the United States. Our partners in China include Harbin Pharmaceutical Group Corporation, North China Pharmaceutical Corporation, Xian Drug Evaluation Center, and Hangzhou AmProtein Biotechnology Co., Ltd. www.amprotein-china.com. In America, AmProtein is a part of the California Biotechnology Research Consortium. The Consortium consists of companies started by well-known ex-Amgen scientists. See www.calbioresearch.com for more information.