Future Directions

Selected Nobel Laureates & Their Contributions to Biotechnology

Year Prize Name(s) For...
2007 Physiology or Medicine Mario R. Capecchi, Sir Martin J. Evans, Oliver Smithies their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells
2006 Physiology or Medicine Andrew Z. Fire, Craig C. Mello for their discovery of RNA interference - gene silencing by double-stranded RNA
2003 Physiology or Medicine Paul C. Lauterbur, Sir Peter Mansfield for their discoveries concerning magnetic resonance imaging
2002 Chemistry John B. Fenn, Koichi Tanaka, Kurt Wüthrich (Fenn, Tanaka) for their development of soft desorption ionisation methods for mass spectrometric analyses of biological macromolecules, (Wüthrich) for his development of nuclear magnetic resonance spectroscopy for determining the three-dimensional structure of biological macromolecules in solution
1993 Chemistry Kary B. Mullis, Michael Smith (Mullis) for his invention of the polymerase chain reaction (PCR) method, (Smith) for his fundamental contributions to the establishment of oligonucleotide-based, site-directed mutagenesis and its development for protein studies
1980 Chemistry Paul Berg, Walter Gilbert, Frederick Sanger (Berg) for his fundamental studies of the biochemistry of nucleic acids, with particular regard to recombinant-DNA, (Gilbert, Sanger) for their contributions concerning the determination of base sequences in nucleic acids
1962 Physiology or Medicine Francis Harry Compton Crick, James Dewey Watson, Maurice Hugh Frederick Wilkins for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material
1959 Physiology or Medicine Severo Ochoa, Arthur Kornberg for their discovery of the mechanisms in the biological synthesis of ribonucleic acid and deoxyribonucleic acid


Internal R&D News

  1. Taking advantage of AmProtein's discovery of the "GC-rich" gene expression method, we are working on plant super-expression technology for the future development of molecular farming, with the goal of transforming traditional farming into molecular farming and biofuel farming.
  2. By taking advantage of AmProtein's Current perfusion bioreactor system, AmProtein is working on 300-600 L large scale VERO and MDCK culture systems to completely solve the human and animal vaccine production problem.
  3. By working with a Chinese company, AmProtien is working on biodegradable plastic bag-based system and making 'green' bioreactors.
  4. By taking advantage of AmProtein's non-sparging O2 transfer method and Current perfusion bioreactor system, AmProtein has successfully conducted rabbit and goat whole-blood culture in vitro and experiments returning the cultured blood to the host. These positive results suggest the future success of a 'safe' artificial lung machine, not only for open heart and lung transplant surgeries, but also for in vitro stem cell induction and radiation/chemo therapy to treat blood cancers.
  5. By taking advantage of AmProtein's two discoveries and protein production platform, AmProtein is working on more dual domain drugs for worldwide patent applications.
  6. By taking advantage of AmProtein's two discoveries and protein production platform, Amprotein is working on more Hyper-G fusion long-acting generic drugs for worldwide patent applications.
  7. By taking advantage of AmProtein's two discoveries and protein production platform, Amprotein is working on culture medium optimization and metabolic pathway optimization.

THINKING AHEAD

AmProtein welcomes collaboration from academic institutions to work on some important issues in the new biotech era:

  • A study regarding specifically over-expressing endogenous genes by using targeted homologous recombination to introduce a GC-rich structure into the endogenous gene-flanking regions and its use for commercial applications.
  • A study regarding the linkages between GC-rich regions in animal/plant genomes and tissue-specific or developmental stage-specific gene expression: the nature of epigenetics and GC-rich structure.
  • A study regarding our discovered novel O2 transfer method and safely culturing in vitro/returning human whole-blood cells for potential medical breakthrough to treat blood cancer and stem cell induction, in addition to applications as an artificial lung.